ACADEMIC QUALIFICATION

                              2011            Ph.D. (Plant Taxonomy), Kyung Hee University, Seoul, South Korea

Dissertation- Phytochemical Constituents of Desmostachya bipinnata and Rhus parviflora from Nepal

                              1998            M.Sc. (Botany), Tribhuvan University, Kathmandu, Nepal

1996             B.Sc. (Biology), Tribhuvan University, Kathmandu, Nepal

 

Research Interest

 

• Biodiversity
• Isolation and identification of secondary metabolites of medicinal and functional food value from natural sources.

 

Work Experience

1. Founder director (2016-date) Himalayan Biome Research Institute (P) Ltd, Kathmandu Nepal
2. Postdoctoral fellow (February 2014-February 2015) Biochemistry Laboratory, Subtropical Horticulture Research Institute, Faculty of Biotechnology, College of Applied Life Science, Jeju National University S. Korea
3. Postdoctoral fellow (September 2011-December 2013) Natural Products Chemistry Laboratory, Graduate School of Biotechnology, College of Life Sciences and Resources, Kyung Hee University, S. Korea.
4. Lecturer (December 2002- August 2008) Ecology Teacher, Patan Multiple Campus, Tribhuvan University, Lalitpur.

 

Publications

1. Krishna K. Shrestha, Yadu N. Paudel, Krishna D. Manandhar, Gyandra P. Ghimire, Sangho Choi and Sabina Shrestha. 2017. Bio-prospecting of plant resources for validation of indigenous knowledge and the search for novel  herbal drugs in Nepal. In: Karki, M., Hill, R., Xue, D., Alangui, W., Ichikawa, K. and Bridgewater P. (eds.). Knowing our Lands and Resources: Indigenous and Local Knowledge and Practices related to Biodiversity and Ecosystem Services in Asia. Knowledges of Nature 10. UNESCO: Paris, 156-168.
2. Sabina Shrestha, Yeon Woo Song, Hyeonji Kim, Dong Sun Lee, and Somi Kim Cho (2016). Sageone, a diterpene from Rosmarinus officinalis, synergizes with cisplatin cytotoxicity in SNU-1 human gastric cancer cells. Phytomedicine, 23(1), 1671–1679.
3. Sabina Shrestha, Ji-Hae Park, Jin Gyeong Cho, Dae-Young Lee, Somi Kim Cho, Dong-Sun Lee, Nam-In Baek (2016). Phytochemical Investigation of Rhus Parviflora fruit from Nepal. Chemistry of Natural Compounds, 52(4), 715-718.
4. Sabina Shrestha, Ji-Hae Park, Jin Gyeong Cho, Dae-Young Lee, Rak-Hun Jeong, Jae-Taek Han, Somi Kim Cho, Dong-Sun Lee, Nam-In Baek (2016). Phytochemical Constituents of the Urena lobata Chemistry of Natural Compounds, 52(1), 178-180.
5. Publication reported for isolation 14 compounds from Urena lobata fruit together with new compound 2-hydroxy-4(1H)-quinolinone for first time from nature.
6. Sabina Shrestha, Ji-Hae Park, Jin Gyeong Cho, Dae-Young Lee, Rak-Hun Jung, Myoung-Chong Song, Somi Kim Cho, Dong-Sun Lee, Nam-In Baek (2016). Phytochemical constituents from the florets of tiger grass Thysanolaena latifolia from Nepal. Journal of Asian Natural Products Research, 18(2), 206-213.
7. Sabina Shrestha, Ji-Hae Park, Jin Gyeong Cho, Dae-Young Lee, Ji-Hyun Kang, Hua Li, Tae-Sook Jeong, Somi Kim Cho, Dong-Sun Lee, Nam-In Baek (2015). Low Density Lipoprotein-oxidation Inhibitory Phytochemicals from the Fruits of Rhus parviflora. Journal of Applied Biological Chemistry, 58(2), 109-112.
8. Ho Bong Hyun, Sabina Shrestha, Kyung Hwan Boo, Somi Kim Cho (2015). Evaluation of antioxidant potential of ethyl acetate fraction of Rosmarinus officinalis and its major components. Journal of Korean Society for Applied Biological Chemistry, 58(5), 715–722.
9. Bishnu Prasad Neupane, Komal Prasad Malla, Atis Kaundinnyayana, Prakash Poudel, Rashmi Thapa, Sabina Shrestha (2015). Antioxidant properties of honey from different altitudes of Nepal Himalayas. Polish Journal of Food and Nutrition Science, 65(2), 87–91.
10. Yeon Woo Song, Sabina Shrestha, Rajendra Gyawali, Dong-Sun Lee, Somi Kim Cho (2015). Citrus unshiu leaf extract containing phytol as a major compound induces autophagic cell death in human gastric adenocarcinoma AGS cells. Journal of the Korean Society for Applied Biological Chemistry 58(2), 257-265.
11. Jin-Gyeong Cho, Jeongran Huh, Rak-Hun Jeong, Byeong-Ju, Cha, Sabina Shrestha, Dong-Geol Lee, Hee-Cheol Kang, Ji-Young Kim and Nam-In Baek (2015). Inhibition effect of phenyl compounds from the Oryza sativa roots on melanin production in murine B16-F10 melanoma cells. Natural Product Research, 29(11), 1052–1054.
12. Jin-Gyeong Cho, Jeong, Byeong-Ju, Cha, Sang Min Lee, Sabina Shrestha, Rak-Hun Jeong, Dong-Sun Lee, Youn-Chul Kim and Nam-In Baek (2015). Diterpenes from the Roots of Oryza sativa and their inhibition activity on NO Production in LPS-stimulated RAW264.7 macrophages. Chemistry & Biodiversity 12(9), 1356-1364.
13. Jin-Gyeong Cho, Jeong, Byeong-Ju, Cha, Woo-Duck Seo, Rak-Hun Jeong, Sabina Shrestha, Ji-Young Kim, Hee-Cheol Kang and Nam-In Baek (2015). Feruloyl sucrose esters from Oryza sativa roots and their tyrosinase inhibition activity, Chemistry of Natural Compounds, 51(6), 1094-1098.
14. Ji-Hae Park, Ye-Jin Jung, Jae-Woo Jung, Sabina Shrestha, Daeseok Han, Dong Wook Lim and Nam-In Baek (2015). Two new isoarylbenzofuran diglucosides from the root bark of Morus alba. Journal of Asian Natural Products Research, 17(4), 357-363.
15. Barna Bahadur Thapa, Saroj Panthi, Rajesh Kumar Rai, Uttam Babu Shrestha, Achyut Aryal, Sabina Shrestha, Bhushan Shrestha (2014). An assessment of Yarsagumba (Ophiocordyceps sinensis) collection in Dhorpatan Hunting Reserve, Nepal. Journal of Mountain Science 11(2), 555-562.
16. Ji-Hae Park, Mohamed Antar Aziz Mohamed, Ye-Jin Jung, Sabina Shrestha, Tae Hoon Lee, Chang-Ho Lee, Daeseok Han, Jiyoung Kim, Nam-In Baek (2014). Germacrane sesquiterpenes isolated from the rhizome of Curcuma xanthorrhiza inhibit UVB-induced upregulation of MMP-1, -2, and -3 expression in human keratinocytes. Archives of Pharmacal Research, 38(1), 1752-1760.
17. Ye-Jin Jung, Ji-Hae Park, Kyeong-Hwa Seo, Sabina Shrestha, Dong-Sung Lee, Youn-Chul Kim, Hee-Cheol Kang, Jiyoung Kim, Nam-In Baek (2014). Phenolic compounds from the stems of Zea mays and their pharmacological activity, Journal of Korean Society for Applied Biological Chemistry 57(3), 379-385.
18. Ji-Hae Park, Ye-Jin Jung, Jae-Woo Jung, Sabina Shrestha, Dong Wook Lim, Daeseok Han and Nam-In Baek (2014).) A new flavonoid glycoside from the root bark of Morus alba Natural Product Research, 28(21) 1859–1863.
19. Ji-Hae Park, Dae-Young Lee, Su-Yeon Kim, Sabina Shrestha, Myun-Ho Bang, Geum-Soog Kim, and Nam-In Baek (2014). New hydroxy fatty acids from Bombyx mori Chemistry of Natural Compounds, 50(5), 801-803.
20. Sabina Shrestha, Sathishkumar Natarajan, Ji-Hae Park, Dae-Young Lee, Jin-Gyeong Cho, Geum-Soog Kim, Yong-Jin Jeon, Seung-Woo Yeon,  Deok-Chun Yang, and Nam-In Baek (2013). Flavonoid based inhibitors of CDK5/p25 inhibitors from Rhus parviflora. Bioorganic & Medicinal Chemistry Letters,  23(18), 5150–5154.
21. Sabina Shrestha, Atmaz Kumar Shrestha, Ji-Hae Park, Dae-Young Lee, Jin-Gyeong Cho, and Nam-In Baek (2013). Review on pharmacologically active metabolites from Yarsagumba (Ophiocordyceps sinensis), an epitome of Himalayan elixir. Nepal Journal of Science and Technology, 14(2), 49-58.
22. Sabina Shrestha, Dae-Young Lee, Ji-Hae Park, Jin-Gyeong Cho, Dong-Sung Lee, Bin Li, Youn-Chul Kim, Geum-Soog Kim, Myun-Ho Bang and Nam-In Baek (2013). Phenolic components from Rhus parviflora fruits and their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages. Journal of Natural Products Research, 27(23), 2244-2247.
23. Sabina Shrestha, Dae-Young Lee, Ji-Hae Park, Jin-Gyeong Cho, Dong-Sung Lee, Bin Li, Youn-Chul Kim, Yong-Jin Jeon, Seung-Woo Yeon and Nam-In Baek (2013). Flavonoids from the fruits of Rhus parviflora attenuate glutamate-induced neurotoxicity in HT22 cells. Food Science and Biotechnology, 22(4), 895-902.
24. Rak-Hun Jeong, Qian Wu, Jin-Gyeong Cho, Dae-Young Lee, Sabina Shrestha, Min-Ho Lee, Kyung-Tae Lee, Myung-Sook Choi, Tae-Sook Jeong, Eun-Mi Ahn, Hae-Gon Chung, Yeong-Deok Rho, Nam-In Baek (2013). Isolation and identification of flavonoids from the roots of Brassica rapa Journal of Applied Biological Chemistry 56(1), 23−27.
25. Kyeong-Hwa Seo, Dae-Young Lee, Dong-Sung Lee, Ji-hae Park, Rak-Jun Jeong, Ye-Jin Jung, Sabina Shrestha, In-Sik Chung, Geum-Soog Kim, Youn-Chul Kim, Nam-In Baek (2013). Neolignans from the fruits of Magnolia obovata and their inhibition effect on NO production in LPS-induced RAW 264.7 cells. Planta Medica 79(14), 1335-1340.
26. Dae-Young Lee, Jae Kwang Kim, Sabina Shrestha, Kyeong-Hwa Seo, Youn-Hyung Lee, Hyung-Jun Noh, Geum-Soog Kim, Yong-Bum Kim, Seung-Yu Kim and Nam-In Baek (2013). Quality evaluation of Panax ginseng roots using a rapid resolution LC-QTOF/MS-based metabolomics approach. Molecules, 18(12), 14849-14861.
27. Jin-Gyeong Cho, Dae-Young Lee, Sabina Shrestha, Sang-Kap Lee, Hyun-Mi Kang, Sung-Ho Son, Deok-Chun Yang, and Nam-In Baek (2013). Three new  ginsenosides  from  the  heat-processed roots  of  Panax  ginseng. Chemistry of Natural Compounds, 49(5), 882-887.

 

28. Jin-Gyeong Cho, Na-Young Song, Tae-Gyu Nam, Sabina Shrestha, Hee-Jung Park, Ha-Na Lyu,
    Dae-Ok Kim, Gihwan Lee, Young-Min Woo, Tae-Sook Jeong, and Nam-In Baek (2013). Flavonoids from the Grains of C1/R‑S Transgenic Rice, the Transgenic
    Oryza sativa japonica, and Their Radical Scavenging Activities. Journal of Agricultural and Food Chemistry, 61(43), 10354−10359.

 

29. Sabina Shrestha, Ji-Hae Park, Dae-Young Lee, Jin-Gyeong Cho, , Suengmok Cho, Hye-Jin Yang, Hye-Im Yong, Min-Seok Yoon, Dae-Seok Han and Nam-In Baek (2012). Rhus parviflora and its biflavonoid constituent, Rhusflavone, induce sleep through the positive allosteric modulation of GABA_A-benzodiazepine receptors. Journal of Ethnopharmacology 142(1), 213–220.
30. Sabina Shrestha, Ji-Hae Park, Dae-Young Lee, Jin-Gyeong Cho, Woo-Duck Seo, Hee Cheol Kang, Ki-Hyun Yoo, In-Sik Chung, Yong-Jin Jeon, Seung-Woo Yeon, and Nam-In Baek (2012). Cytotoxic and neuroprotective biflavonoids from the fruit of Rhus parviflora. Journal of Korean Society for Applied Biological Chemistry, 55(4), 557-562.
31. Sabina Shrestha, Dae-Young Lee, Ji-Hae Park, Jin-Gyeong Cho, Woo-Duck Seo, Hee Cheol Kang, Yong-Jin Jeon, Seung-Woo Yeon, Myun-Ho Bang and Nam-In Baek (2012). Flavonoid glycosides from the fruit of Rhus parviflora and inhibition of cyclin dependent kinases by Hyperin. Journal of Korean Society for Applied Biological Chemistry, 55(5), 689-693.
32. Sabina Shrestha, Bhushan Shrestha, Ji-Hae Park, Dae-Young Lee, Jin-Gyeong Cho, and Nam-In Baek (2012). Chemical constituents of Yarsagumba (Ophiocordyceps sinensis (Berk.) Sung et al.), a valued traditional Himalayan medicine. Nepal Journal for Science and Technology, 13(1), 43-58.
33. Dae-Young Lee, Sabina Shrestha, Woo-Duck Seo, Min-Ho Lee, Tae-Sook Jeong, Jun Hyun Cho, You Chun Song, Hang Won Kang, Yeong-Deok Rho, and Nam-In Baek (2012). Structural and Quantitative Analysis of Antioxidant and Low-Density Lipoprotein-Antioxidant Flavonoids from the Grains of Sugary Rice. Journal of Medicinal Food, 15(4), 399-405.
34. En-Ji Cui, Na-Young Song, Sabina Shrestha, In-Sik Chung, Ji-young Kim, Tae-Sook Jeong, and Nam-In Baek (2012). Flavonoid glycosides from cowpea seeds (Vigna sinensis) inhibit LDL oxidation. Journal of Food Science and Biotechnology, 21(2), 619-624.
35. Qian Wu, Myun-Ho Bang, Dae-Young Lee, Jin-Gyeong Cho, Rak-Hun Jeong, Sabina Shrestha, Kyung-Tae Lee, Hae-Gon Chung, Eun-Mi Ahn, and Nam-In Baek (2012). New indoles from the roots of Brassica rapa campestris. Chemistry of Natural Compounds, 48(2), 281-284.
36. Sabina Shrestha, Ji-Hae Park, Dae-Young Lee, Jin-Gyeong Cho, En-Ji Cui, In-Sik Chung, Byoung-Mog Kwon, Moon-Hee Cho, Tae-Sook Jeong, and Nam-In Baek, N.I. (2011). A new xanthene from Desmostachya bipinnata (L.) Stapf inhibits signal transducers and activation of transcription (STAT3) and low-density lipoprotein - oxidation. Journal of Korean Society for Applied Biological Chemistry 54(2), 308-311.
37. Sabina Shrestha, Ha-Na Lyu, Ji-Hae Park, Dae-Young Lee, Jin-Gyeong Cho, J.G., En-Ji Cui, In-Sik Chung, and Nam-In Baek (2011). Sterols from the leafy culms of Desmostachya bipinnata (L.) Stapf. Chemistry of Natural Compounds, 47(5), 852-853.
38. Sabina Shrestha, Ji-Hae Park, Dae-Young Lee, Jin-Gyeong Cho, Jong-Su Yoo, Seung-Woo Yeon, Hee Cheol Kang and Nam-In Baek (2011). Constituents of Machilus thunbergii bark and inhibition of cyclin-dependent kinases (CDKs) by Procyanidin B2. Journal of Korean Society for Applied Biological Chemistry 54(6), 998-1003.
39. Sabina Shrestha, Ji-Hae Park, Dae-Young Lee, Jin-Gyeong Cho, Do-Gyeong Lee, Moon-Hee Cho, Tae-Sook Jeong, Hee-Cheol Kang and Nam-In Baek (2011). Inhibition of LDL-oxidation, ACAT-1, and ACAT-2 by lignans from the bark of Machilus thunbergii. Journal of Applied Biological Chemistry 54(1), 63-66.
40. Gyu-Won Huh, Ji-Hae Park, Sabina Shrestha, Youn-Hyung Lee, Eun-Mi Ahn, Hee-Cheol Kang and Nam-In Baek (2011). Sterols from Lindera glauca Blume stem wood. Journal of Applied Biological Chemistry 54(4), 309-312. http://ksabc.or.kr/admin/contribute/journal_jabc/epaper/2011_54_4_309-312.pdf
41. Kyeong-Hwa Seo, Mi-Young Baek, Dae-Young Lee, Sabina Shrestha, Hee Cheol Kang, Yeong-Deok Rho, and Nam In Baek (2010). Isolation of secondary metabolites from Lindera obtusiloba B Research Collection of Institute of Life Science and Resources, Kyung Hee University, 29, 24-28.
42. Ji-Hae Park, Ha-Na Lyu, Do-Gyeong Lee, Jae-Woong Lee, Sabina Shrestha, Kyung-Tai Kim, Youn-Hyung Lee, and Nam-In Baek (2009). Isolation and identification of phenolic acid derivatives from Kalopanacis cortex. Research Collection of Institute of Life Science and Resources, Kyung Hee University, 28, 72-76.
43. Ha-Na Lyu, Ho-Young Kwak, Ji-Hae Park, Lakoon Jung, En-Ji Cui, Sabina Shrestha, Kyong-Tai Kim, In-Sik Chung, and Nam-In Baek (2008). Isolation of lignan from Kalopanacis cortex. Research Collection of Institute of Life Science and Resources, Kyung Hee University, 27, 75-78.

 

44. Mi-Young Baek, Dae-Young Lee, Jin-Gyeong Cho, Ha-Na Lyu, Sabina Shrestha, Eun-Mi Ahn, Jae-Woong Lee, Youn-Hyung Lee, and Nam-In Baek (2008). Isolation of sterols from the stem bark of Alibizia julibrissin Research Collection of Institute of Life Science and Resources, Kyung Hee University, 27, 50-54.

 

Patent Rights for Rhus parviflora

KR 201610748 A 20160128 nerve protection 

KR 201610747 A 20160128 preventing and treating neurodegenerative disease